Corion Fertility Clinic

Recurrent Pregnancy Loss Testing and Treatment

Miscarriage is the loss of a pregnancy before viability. Occurring in 15-20% of all pregnancies, it is the most common complication of pregnancy. The individual risk may vary depending on age and other factors. The unfortunate fact of miscarriages is that the vast majority of them are not preventable because they are due to developmental or genetic problems in the embryo or fetus that cannot be treated.

Recurrent Pregnancy Loss (RPL) or Recurrent Miscarriage (RM) affects from 1-5 % of the reproductive age couples.

Causes of RPL

Uterine Cavity

Uterine abnormalities can be congenital or acquired as a woman ages. Transvaginal ultrasound can only diagnose a few of the important uterine anomalies, and frequently further testing is required. Testing the uterine cavity can be done with a hysteroscope, a small camera placed into the uterine cavity through the cervix. Other testing methods such as hysterosalpingogram (HSG), saline infused sonogram or MRI can also be used. The physician will recommend the most appropriate test for you after basic evaluation.

Getting accurate records about gestational age at the time of loss is important in evaluating causes of pregnancy loss. If your losses occurred after 14 weeks, you may need an evaluation by a maternal fetal medicine specialist for a cerclage. A cerclage is a stitch placed around the cervix to prevent premature cervical dilation. If in case you have suffered more than 2 fetal losses & have even tried Os tightening, you may now need to think of Gestational Surrogacy.

Genetic Factors

Studies have concluded that about half of all first trimester miscarriages are the result of chromosomal abnormalities. They are related to the age of the woman and are more likely to occur with advancing maternal age.Increased DNA damage in the sperm may also be a contributing factor. Further research is needed in this area. We offer testing for the Sperm DNA Fragmentation at our clinic. For details kindly write to us at

Hormonal Factors

There are several hormonal imbalances that can contribute to miscarriage rates. These can be evaluated with simple blood tests and treated if present.

Hematologic and Immunologic Factors

Several blood disorders have been implicated in recurrent miscarriages. Women with abnormal blood clotting may be predisposed to early or late miscarriage.

Treatment Options

There are many successful treatments available and the optimal treatment recommended will depend on the results of a thorough evaluation. All patients with recurrent pregnancy loss should be monitored closely during early pregnancy. Blood thinners, hormonal supplements or vitamins may be prescribed. In some cases Preimplantation Genetic Diagnosis, Egg or Sperm donation or Gestational Surrogacy may be recommended. It is important for all patients to know that there are multiple options available for everyone and that we are here to provide you the much needed professional advice and support.

At Corion, we run a very successful Third Party Reproduction Program with a success rate of 70-80%. You can read more about our program on Donor Egg IVF and Gestational Surrogacy.

For more information related to Recurrent Pregnancy Loss Testing and treatment, you can write an email to us at